Laminins in metabolic tissues

Highlights

• Laminins are extracellular matrix proteins that play diverse roles in metabolic tissues.
• Adipose tissue laminins regulate energy expenditure and insulin sensitivity.
• Pancreatic laminins appear to promote insulin secretion and β-cell proliferation.
• Altered laminin expression is seen in metabolic disorders such as insulin resistance and obesity.
• Due to their extracellular location, laminins may be inviting targets for the treatment of metabolic disorders.

Laminins are extracellular matrix proteins that reside in the basement membrane and provide structural support in addition to promoting cellular adhesion and migration. Through interactions with cell surface receptors, laminins stimulate intracellular signalling cascades which direct specific survival and differentiation outcomes. In metabolic tissues such as the pancreas, adipose, muscle, and liver, laminin isoforms are expressed in discrete temporal and spatial patterns suggesting that certain isoforms may support the development and function of particular metabolic cell types. This review focuses on the research to date detailing the expression of laminin isoforms, their potential function, as well as known pathways involved in laminin signalling in metabolic tissues.

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Endocrinology and Metabolism: Open Access
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