Cancer Biomarkers
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Many of the inventions in drug development are propelled by new research methods and the growth of new therapeutic options, such as immune-related oncology drugs, personalized medicine, stem cells, and biologics. The long run of the Pharmaceutical Industry lies in overcoming obstructions to development through propels in information analytics. The pharmaceutical and healthcare industry is quickly coming to terms with advanced innovation. Healthcare industry rapidly raise like a pharma company can utilize different computerized showcasing stages for sharing instructive substance to assist their potential and existing clientele, like clarifying indications, causes, diagnosis, cure etc. for relevant diseases. Cancer biomarkers have gained significant importance in the drug-development process, and the market is an emerging segment.
To gain an understanding of the market dynamics, market size and competitive landscape, a detailed analysis of cancer biomarker market and cancer profiling technologies and new developments is needed. Microarray technologies provide analysis of tens of thousands of molecules for a variety of assays, including drug binding, molecular interactions, enzyme activity and pathway identification.
These microarrays, which include DNA microarrays, protein microarrays, tissue microarrays, low complexity microarrays and carbohydrate microarrays, are excellent tools for gene expression profiling, biomarker profiling and diagnostics. Targeted cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecules that are involved in the growth, progression, and spread of cancer. Targeted cancer therapies are sometimes called "molecularly targeted drugs," "molecularly targeted therapies," "precision medicines," or similar names.
Pharmaceutical and biotechnology researchers use microarrays to streamline drug target identification, selection, validation and predictive testing. Rapid growth in the clinical research and diagnostic devices markets holds great potential for applications of microarray technology, including basic research, clinical trials and diagnostic devices.
This report examines various microarray platforms and the technologies that are utilized to detect DNA and proteins for the purpose of drug discovery, disease diagnosis and disease monitoring. This report also examines companies that are actively developing and marketing microarray instrumentation or microarray biochips.The report categorizes the biomarkers and profiling market and provides market data, market drivers, trends and opportunities, top-selling products, key players and competitive outlook.
This report will also provide market tables and also provides company profiles. Another vital trend providing a substantial push to breast cancer therapeutics market size is the advancements in healthcare infrastructure. Of late, the expanding healthcare business space is blazing with abundance of innovations by renowned giants who have been incessantly attempting to effectuate commercialization of innovative drugs that prove to be extensively beneficial for the consumers - a trend that is leaving a perpetual impact on the product matrix breast cancer therapeutics market. Another approach to identify potential targets is to determine whether cancer cells produce mutant (altered) proteins that drive cancer progression. For example, the cell growth signaling protein BRAF is present in an altered form (known as BRAF V600E) in many melanomas. Vemurafenib (Zelboraf®) targets this mutant form of the BRAF protein and is approved to treat patients with inoperable or metastatic melanoma that contains this altered BRAF protein.
Researchers also look for abnormalities in chromosomes that are present in cancer cells but not in normal cells. Sometimes these chromosome abnormalities result in the creation of a fusion gene (a gene that incorporates parts of two different genes) whose product, called a fusion protein, may drive cancer development. Such fusion proteins are potential targets for targeted cancer therapies.
For example, imatinib mesylate (Gleevec®) targets the BCR-ABL fusion protein, which is made from pieces of two genes that get joined together in some leukemia cells and promotes the growth of leukemic cells.
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Jack Leo | Managing Editor
Colorectal Cancer: Open Access
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